Comparison in leprosy patients of Fernandex and Mitsuda reactions using human and armadillo antigens. A double-blind study.
نویسندگان
چکیده
The Mitsuda and Fernandez reactions to bacilli prepared from lesions of human patients and bacilli from infected armadillos were studied in 112 leprosy patients. It was observed that there is no substantial difference when armadillo lepromin is used instead of human lepromin except that a larger induration occurs with the use of the armadillo lepromin in a majority of cases. The number of those reporting a burning sensation at the armadillo lepromin injection site was slightly higher in lepromatous patients; whereas the burning sensation was observed at the human lepromin injection site by the tuberculoid cases. With the significant information compiled in this study, it is concluded that lepromin prepared from bacilli obtained from infected armadillos is as effective as that prepared from bacilli obtained from the lesions of leprosy patients.
منابع مشابه
Mitsuda reaction in armadillos Dasypus novemcinctus using human and armadillo derived antigens
The armadillo has been an important experimental model for leprosy, besides it is still an important resource for bacilli. Despite the innumerous studies about armadillos of the Genus Dasypus, little is known about the real susceptibility of this species to the Hansen’s bacillus after experimental infection with M. leprae. Many authors have reported that 80% of the inoculated animal will develo...
متن کاملPositive Mitsuda lepromin reactions in long-term treated lepromatous leprosy.
Twenty-four lepromatous (LL) patients, treated for 22 to 40 years with chemotherapy, including sulphones and with multidrug therapy, were tested with standard Wade-Mitsuda lepromin. Thirteen gave weak positive (3-4 mm) Mitsuda reactions, confirmed histologically in the ten whose reactions were biopsied. Six of the eleven negative reactors were partly accounted for by a history of relapse, and t...
متن کاملComparison of reactions to human and armadillo lepromins in leprosy.
To assess the usefulness of Mycobacterium leprae-infected armadillo tissue as a substitute for human lepromas for the manufacture of lepromin, we compared skin reactions to preparations from these two sources in 115 leprosy patients. The patient sample represented all the primary clinical forms of leprosy. Lepromin derived from the armadillo (lepromin-A) provoked the same pattern of responses a...
متن کاملComparative study of the 48-hour response to soluble antigens obtained from human and armadillo leprosy material in lepromatous leprosy patients and normal persons, contacts of leprosy patients.
We prepared antigens by precipitating with 80% ammonium sulfate supernatants of human and armadillo antigen at a concentration of 160 X 10(6) bacteria per ml. The precipitate was resuspended, dialyzed and filtered. The antigen obtained was inactivated with trypsin during 30 minutes. The tests made with these antigens were negative for the 48-hour test in lepromatous patients and highly positive...
متن کاملCorrection: Safety and Efficacy Assessment of Two New Leprosy Skin Test Antigens: Randomized Double Blind Clinical Study
BACKGROUND New tools are required for the diagnosis of pre-symptomatic leprosy towards further reduction of disease burden and its associated reactions. To address this need, two new skin test antigens were developed to assess safety and efficacy in human trials. METHODS A Phase I safety trial was first conducted in a non-endemic region for leprosy (U.S.A.). Healthy non-exposed subjects (n = ...
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ورودعنوان ژورنال:
- International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
دوره 43 3 شماره
صفحات -
تاریخ انتشار 1975